Arvaniti K, Ricquier D, Champigny O, Richard D
Département de physiologie, Faculté de médecine, Université Laval, Québec, Canada.
Endocrinology. 1998 Sep;139(9):4000-3. doi: 10.1210/endo.139.9.6287.
The present study was conducted to assess the interaction effect of leptin and corticosterone on food intake and the expression of uncoupling protein 1 (UCP1) mRNA in interscapular brown adipose tissue (IBAT). To this end, a 3 x 3 factorial experiment was designed in which adrenalectomized (ADX) lep(ob)/lep(ob) mice were subjected to three doses of corticosterone and three doses of leptin. The results confirm the anorectic and orexigenic effects of leptin and corticosterone, respectively. The results also emphasize the abilities of leptin and corticosterone to respectively increase and reduce the expression of UCP1 mRNA in IBAT. The effects of leptin and corticosterone on food intake and the expression of UCP1 mRNA translated into effects on body weight and body composition; leptin reduced body weight and corticosterone increased the weight of IBAT. The present results do not provide evidence for leptin-corticosterone interactions in the control of food intake and thermogenesis. Corticosterone increased food intake and reduced the expression of IBAT UCP1 regardless of the leptin status, and leptin reduced food intake and induced the expression of IBAT UCP1 independently of the corticosterone levels.
本研究旨在评估瘦素和皮质酮对食物摄入量以及肩胛间棕色脂肪组织（IBAT）中解偶联蛋白1（UCP1）mRNA表达的相互作用。为此，设计了一个3×3析因实验，对肾上腺切除的（ADX）lep(ob)/lep(ob)小鼠给予三种剂量的皮质酮和三种剂量的瘦素。结果分别证实了瘦素的厌食作用和皮质酮的促食欲作用。结果还强调了瘦素和皮质酮分别增加和降低IBAT中UCP1 mRNA表达的能力。瘦素和皮质酮对食物摄入量及UCP1 mRNA表达的影响转化为对体重和身体组成的影响；瘦素降低体重，皮质酮增加IBAT的重量。目前的结果并未为瘦素 - 皮质酮在食物摄入控制和产热中的相互作用提供证据。无论瘦素状态如何，皮质酮均增加食物摄入量并降低IBAT中UCP1的表达，而瘦素则独立于皮质酮水平降低食物摄入量并诱导IBAT中UCP1的表达。
