Hyman S E
National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Exp Clin Psychopharmacol. 2000 Aug;8(3):271-2. doi: 10.1037//1064-1297.8.3.271.
Because all health conditions for which the National Institute of Mental Health (NIMH) is responsible manifest at the level of behavior, and all interventions must have an impact at the behavioral level, NIMH is firmly committed to the support of behavioral science. In an era in which research in areas that some view as reductionist--for example, genomics, genetics, functional genomics and proteomics, and molecular science--is especially promising, NIMH is striving to maintain a balance in its portfolio with studies that explore integrative aspects of biology, including behavior. Without this perspective, new information about fundamental processes will prove ultimately to be shallow. This commentary discusses how understanding of brain and behavior in mental illness and health calls for integrating bottom-up research that studies brain and behavior through genes and molecules, with top-down research that examines the impact of environment.
由于美国国立精神卫生研究所（NIMH）负责的所有健康状况都在行为层面表现出来，并且所有干预措施都必须在行为层面产生影响，因此NIMH坚定致力于支持行为科学。在一个某些人认为是还原论的领域（例如基因组学、遗传学、功能基因组学和蛋白质组学以及分子科学）的研究特别有前景的时代，NIMH正在努力通过探索生物学综合方面（包括行为）的研究来在其研究组合中保持平衡。没有这种视角，关于基本过程的新信息最终将被证明是肤浅的。本评论讨论了对精神疾病和健康中的大脑与行为的理解如何需要将通过基因和分子研究大脑与行为的自下而上的研究，与考察环境影响的自上而下的研究结合起来。
