Rapaport F T, Lawrence H S, Bachvaroff R, Cannon F D, Blumenstock D, Mollen N, Ayvazian J H, Ferrebee J W
J Exp Med. 1975 Jul 1;142(1):120-38. doi: 10.1084/jem.142.1.120.
20 Cooperstown beagles of known DL-A genotypes (B" dogs) were exposed to supralethal total body irradiation and received a bone marrow allograft from a DL-A identical donor (A" dog); the resulting chimeras have survived uneventfully for 882, 1466 days, with no evidence of secondary disease, and have been tolerant to kidney and skin allografts obtained from the donor of marrow. Treatment of "A" dogs with serum obtained from their long-term "B" chimeras had no significant effect upon the ability of the recipients to reject "B" skin allografts...
20只已知DL-A基因型的库珀斯敦小猎犬（B”型犬）接受了超致死剂量的全身照射，并接受了来自DL-A基因型相同供体（A”型犬）的骨髓同种异体移植；由此产生的嵌合体已分别顺利存活了882天和1466天，没有继发性疾病的迹象，并且对从骨髓供体获得的肾脏和皮肤同种异体移植具有耐受性。用从其长期“B”型嵌合体获得的血清治疗“A”型犬，对受体排斥“B”型皮肤同种异体移植的能力没有显著影响……
