环磷酰胺治疗多发性硬化症病情加重。治疗试验及先导药物研究策略。
Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies.
作者信息
Drachman D A, Paterson P Y, Schmidt R T, Spehlmann R F
出版信息
J Neurol Neurosurg Psychiatry. 1975 Jun;38(6):592-7. doi: 10.1136/jnnp.38.6.592.
Abstract
Cyclophosphamide (CY) has been shown to reverse the signs of experimental allergic encephalomyelitis (EAE) even after the onset of neurological deficits. Because of the analogy of EAE to exacerbations of multiple sclerosis (MS) a clinical trial of CY in acute MS exacerbations was undertaken. A 'sequential criterion' method was used to minimize the size of sample needed for this pilot study. CY failed to alter significantly the course of acute exacerbations of MS. Possible reasons for this failure, and the value of the sequential criterion method in pilot studies, are discussed.
摘要
环磷酰胺（CY）已被证明即使在神经功能缺损出现后也能逆转实验性变应性脑脊髓炎（EAE）的症状。由于EAE与多发性硬化症（MS）病情加重情况相似，因此开展了一项关于CY治疗急性MS病情加重的临床试验。采用“序贯标准”方法以尽量减少该初步研究所需的样本量。CY未能显著改变MS急性病情加重的病程。本文讨论了此次试验失败的可能原因以及序贯标准方法在初步研究中的价值。
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本文引用的文献
1
PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS.多发性硬化症治疗的实验性试验问题：多发性硬化症治疗实验性试验评估小组报告
Ann N Y Acad Sci. 1965 Mar 31;122:552-68. doi: 10.1111/j.1749-6632.1965.tb20235.x.
2
SUPPRESSION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS BY ANTIMETABOLITIES.抗代谢物对实验性变应性脑脊髓炎的抑制作用
Ann N Y Acad Sci. 1965 Mar 31;122:356-68. doi: 10.1111/j.1749-6632.1965.tb20220.x.
3
TISSUE CULTURE STUDIES OF DEMYELINATION.脱髓鞘的组织培养研究
Ann N Y Acad Sci. 1965 Mar 31;122:280-6. doi: 10.1111/j.1749-6632.1965.tb20212.x.
4
Cyclophosphamide: effect on experimental allergic encephalomyelitis in Lewis rats.
Science. 1969 Jul 11;165(3889):191-2. doi: 10.1126/science.165.3889.191.
5
Cyclophosphamide inhibition of experimental allergic encephalomyelitis in guinea pigs.
Arch Int Pharmacodyn Ther. 1969 Nov;182(1):171-7.
6
Relationship of experimental allergic encephalomyelitis to human disease.实验性变应性脑脊髓炎与人类疾病的关系。
Res Publ Assoc Res Nerv Ment Dis. 1971;49:33-49.
7
Cyclophosphamide treatment of experimental allergic encephalomyelitis in Lewis rats.
J Immunol. 1971 Jun;106(6):1473-9.
8
Chemical suppression of adaptive immunity.适应性免疫的化学抑制
Adv Immunol. 1967;6:91-229. doi: 10.1016/s0065-2776(08)60522-2.
9
Cellular hypersensitivity to basic myelin (A1) protein and clinical multiple sclerosis.细胞对碱性髓鞘（A1）蛋白的超敏反应与临床多发性硬化症。
N Engl J Med. 1974 Jul 4;291(1):14-7. doi: 10.1056/NEJM197407042910104.
10
Failure of antilymphocytic globulin therapy in chronic progressive multiple sclerosis.
Neurology. 1973 Jun;23(6):592-8. doi: 10.1212/wnl.23.6.592.
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