Harasawa K
Department of Anesthesiology and Critical Care, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 2000 Jul;75(4):275-81.
The author studied whether the histaminergic system is involved in spinal nociception or not. A nociception-related, slow ventral root potential of rats, which is an integrated output of motoneurons, was recorded as an index of the intensity of nociception when an electric stimulation was applied to the dorsal root. Histamine dissolved in an artificial cerebrospinal fluid caused small reduction in the potential; however, mepyramine (10 nM to 10 microM, as an H1 receptor antagonist), ranitidine (1 nM to 1 microM, as an H2 receptor antagonist), R(-)-alpha-methylhistamine (2 pM to 200 nM, as an H3 receptor agonist), and thioperamide (1 nM to 10 microM, as an H3 receptor antagonist) dose-dependently reduced the potential down to around a half of each control level. These results indicate that the histaminergic system may affect the spinal withdrawal reflex.
作者研究了组胺能系统是否参与脊髓伤害感受。当对大鼠背根施加电刺激时，记录了与伤害感受相关的、作为运动神经元综合输出的大鼠腹侧慢根电位，以此作为伤害感受强度的指标。溶解于人工脑脊液中的组胺使该电位略有降低；然而，作为H1受体拮抗剂的美吡拉敏（10 nM至10 μM）、作为H2受体拮抗剂的雷尼替丁（1 nM至1 μM）、作为H3受体激动剂的R(-)-α-甲基组胺（2 pM至200 nM）以及作为H3受体拮抗剂的硫代哌酰胺（1 nM至10 μM）均呈剂量依赖性地将该电位降低至每个对照水平的一半左右。这些结果表明，组胺能系统可能影响脊髓退缩反射。
