Montagnac R, Clavel P, Delhotal-Landes B, Flouvat B, Poulain S, Schillinger F
Service de néphrologie-hémodialyse, Centre hospitalier de Troyes.
Nephrologie. 2000;21(4):179-83.
Chronic hypotension, although unfrequent in uremic patients on hemodialysis, accentuates the deterioration of patients physical state and thus, their general well-being. These patients often experience acute intradialytic symptoms and respond very poorly to conventional therapies. Well tolerated, midodrine is a suitable and effective choice as it raises blood pressure significantly through its effect on peripheral alpha-adrenergic receptors. The authors report observing the use of midodrine by a dialysis patient during the longest time period published to date, documented by a pharmacokinetic study, and that confirms the excellent results and proves long term tolerance for that drug.
慢性低血压在接受血液透析的尿毒症患者中虽不常见，但会加剧患者身体状况的恶化，进而影响其整体健康。这些患者常出现急性透析期间症状，对传统疗法反应很差。米多君耐受性良好，是一种合适且有效的选择，因为它通过作用于外周α-肾上腺素能受体显著升高血压。作者报告了观察到一名透析患者使用米多君的时间是迄今为止发表的最长时间，并通过一项药代动力学研究记录在案，该研究证实了该药的优异效果并证明了其长期耐受性。
