米多君对血液透析期间症状性低血压的影响
[Effects of midodrine on symptomatic hypotension during hemodialysis].
作者信息
Cotera Alejandro, Alvo Miriam, Sanhueza María Eugenia, Elgueta Leticia, Gormaz Juan Pablo, Ibáñez Carlos, Cuadra Cristián
机构信息
Unidad de Atención Nefrológica Continua, Sección de Nefrología, Departamento de Medicina, Hospital Clínico Universidad de Chile.
出版信息
Rev Med Chil. 2002 Sep;130(9):1009-13.
BACKGROUND
Hypotension occurs in 20% of hemodialysis procedures.
AIM
To study the effects of midodrine on hypotension during hemodialysis.
PATIENTS AND METHODS
Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design.
RESULTS
Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3 +/- 28 mmHg with midodrine and 23.4 +/- 28 mmHg with placebo. Diastolic blood pressure fell 7.3 +/- 11.5 mmHg with midodrine and 11.1 +/- 12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine.
CONCLUSIONS
Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension.
背景
20%的血液透析过程中会出现低血压。
目的
研究米多君对血液透析期间低血压的影响。
患者与方法
对10例接受慢性血液透析且在透析过程中有低血压病史的患者进行研究。采用双盲交叉设计，他们在每次5次透析过程中分别口服10毫克米多君或安慰剂。
结果
在服用米多君或安慰剂期间，透析前的血压水平相似。透析期间，服用米多君时收缩压下降19.3±28毫米汞柱，服用安慰剂时下降23.4±28毫米汞柱。服用米多君时舒张压下降7.3±11.5毫米汞柱，服用安慰剂时下降11.1±12毫米汞柱。米多君使平均动脉压的降低也不那么明显。
结论
对于有症状性低血压的患者，米多君可减轻血液透析期间动脉压的下降。
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