一些新型2-吲哚酮衍生肟类和螺异恶唑啉类化合物的合成及其抗菌活性
Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines.
作者信息
El-Gendy A A, Ahmedy A M
机构信息
Department of Organic Chemistry and Microbiology, Faculty of Pharmacy, Cairo University, Egypt.
出版信息
Arch Pharm Res. 2000 Aug;23(4):310-4. doi: 10.1007/BF02975439.
The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2-hydroxyimino-2-(substituted phenyl)ethyl]-2H-indol-2-ones (21-32) and spiro[3H-indol-3,5'-(4'H)-isoxazol]-2(1H)-ones (33-44) are described. Sixteen of the synthesized compounds were screened in vitro for their growth inhibitory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans and S. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes 28 and 29.
描述了一些新型1,3 - 二氢 - 3 - 羟基 - 3 - [2 - 羟基亚氨基 - 2 - （取代苯基）乙基] - 2H - 吲哚 - 2 - 酮（21 - 32）和螺[3H - 吲哚 - 3,5' - （4'H） - 异恶唑] - 2（1H） - 酮（33 - 44）的合成及光谱分析。对合成的十六种化合物进行了体外筛选，以检测它们对13种微生物的生长抑制活性，即金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌、枯草芽孢杆菌、蜡样芽孢杆菌、产气肠杆菌、大肠杆菌、铜绿假单胞菌、普通变形杆菌、鲍曼不动杆菌、粪产碱菌、白色念珠菌和宫颈葡萄球菌。大多数化合物表现出显著的抗菌活性，尤其是肟28和29。
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