Rindhe S S, Karale B K, Gupta R C, Rode M A
Department of Chemistry, New Arts, Commerce and Science College, Ahmednagar-414 003, India.
Indian J Pharm Sci. 2011 May;73(3):292-6. doi: 10.4103/0250-474X.93519.
The present work describes the synthesis and spectral analysis of some new 3(Z)-{4-[4-(arylsulfonyl)piperazin-1-ylbenzylidene)-1,3-dihydro-2H-indol-2-one (5a-j). Ten of the synthesized compounds were screened in vitro against six species of microorganisms, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Asperigellus niger and Asperigellus clavatus. Most of the compounds exhibited significant antimicrobial activity. All of these compounds were also screened in vitro for the antioxidant activity using DPPH assay. Most of them have shown very significant antioxidant activity.
本研究描述了一些新型3(Z)-{4-[4-(芳基磺酰基)哌嗪-1-基苄叉基]-1,3-二氢-2H-吲哚-2-酮(5a-j)的合成及光谱分析。对合成的十种化合物针对六种微生物进行了体外筛选，这六种微生物分别是金黄色葡萄球菌、化脓性链球菌、大肠杆菌、铜绿假单胞菌、黑曲霉和棒曲霉。大多数化合物表现出显著的抗菌活性。所有这些化合物还使用DPPH法进行了体外抗氧化活性筛选。其中大多数表现出非常显著的抗氧化活性。
