Sauder J M, Dunbrack R L
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Proc Int Conf Intell Syst Mol Biol. 2000;8:296-306.
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
多细胞生物秀丽隐杆线虫的首个可用基因组被用作使用PSI-BLAST进行蛋白质折叠分配的测试案例，随后在与生物学家合作的背景下进行合理的结构建模并解释实验诱变数据。对于具有已知多态性的人类疾病蛋白质也得到了类似结果。
