Lin W T, Robb R A
Mayo Clinic/Foundation, Rochester, Minnesota 55905, USA.
Stud Health Technol Inform. 2000;70:182-8.
Cardiac disorders result mainly from defects in cardiac structure or failure to generate and regulate electrical impulses. Knowledge of the structure, motion patterns, local deformation, and associated electrical activation patterns of the heart is necessary for precise diagnosis and treatment. Electrical and mechanical performance of the heart is strongly influenced by the anisotropic nature of myocardial tissue. Diffusion-encoded MR imaging provides in vivo myocardial fiber track information that can be used for precise simulation of cardiac conduction and contraction. We propose a method that incorporates such fiber track information with a physics-based deformable model to realistically simulate cardiac contraction and subsequent relaxation. The simulation aims to reproduce the myocardial deformation during the heartbeat. The system allows interactive visualization of dynamic 3-D heart structures during the cardiac cycle. In procedures such as catheter ablation, the interactive 4-D model provides updated anatomy and physiology of the patient's heart simultaneously, and can be used to guide the procedure for efficient targeting of the treatment regions.
心脏疾病主要源于心脏结构缺陷或无法产生及调节电冲动。了解心脏的结构、运动模式、局部变形以及相关的电激活模式对于精确诊断和治疗至关重要。心肌组织的各向异性对心脏的电和机械性能有很大影响。扩散编码磁共振成像提供了体内心肌纤维轨迹信息，可用于精确模拟心脏传导和收缩。我们提出了一种方法，将这种纤维轨迹信息与基于物理的可变形模型相结合，以逼真地模拟心脏收缩及随后的舒张。该模拟旨在再现心跳期间的心肌变形。该系统允许在心动周期中交互式可视化动态三维心脏结构。在诸如导管消融等手术中，交互式四维模型可同时提供患者心脏的最新解剖结构和生理信息，并可用于指导手术以有效地靶向治疗区域。
