Kirkpatrick B, Ross D E, Walsh D, Karkowski L, Kendler K S
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore, MD 21228, USA.
Schizophr Res. 2000 Sep 29;45(1-2):57-64. doi: 10.1016/s0920-9964(99)00164-4.
Studies of course, treatment response, biological correlates, and environmental risk factors have suggested that the deficit syndrome of schizophrenia defines a meaningful subgroup within schizophrenia. Probands from the Roscommon Family Study who met criteria for schizophrenia or simple schizophrenia were categorized into deficit (N=22) and nondeficit (N=111). Within schizophrenia, the lifetime prevalence of the deficit syndrome was 16.5%; the percentage of males was 91% compared to 63% in the nondeficit group. The first-degree relatives of deficit probands had a significantly greater social isolation than the relatives of nondeficit probands, despite significantly less severe dysphoria and psychotic-like symptoms. The risk of schizophrenia was 1.75 times greater in the families of deficit compared to nondeficit probands. There were no significant differences in the adjusted morbid risk for nonaffective psychosis, affective disorder, or alcoholism. These results provide further evidence that the deficit syndrome is a marker of a group of patients with clinical and neurobiological characteristics that distinguish them from the rest of schizophrenia. The deficit syndrome may be a useful phenotype in genetic linkage studies.
关于病程、治疗反应、生物学关联及环境风险因素的研究表明，精神分裂症的缺陷综合征在精神分裂症中界定了一个有意义的亚组。来自罗斯康芒家族研究的符合精神分裂症或单纯型精神分裂症标准的先证者被分为缺陷型（N = 22）和非缺陷型（N = 111）。在精神分裂症患者中，缺陷综合征的终生患病率为16.5%；男性比例为91%，而非缺陷组为63%。缺陷型先证者的一级亲属比非缺陷型先证者的亲属有显著更高的社会隔离程度，尽管其烦躁不安和类精神病症状明显较轻。与非缺陷型先证者的家族相比，缺陷型先证者家族中精神分裂症的风险高1.75倍。在非情感性精神病、情感障碍或酒精中毒经调整的发病风险方面没有显著差异。这些结果进一步证明，缺陷综合征是一组具有临床和神经生物学特征、使其有别于其他精神分裂症患者群体的标志。缺陷综合征可能是基因连锁研究中一种有用的表型。
