Kendler K S, McGuire M, Gruenberg A M, Walsh D
Department of Psychiatry and Human Genetics, Medical College of Virginia, Richmond.
Am J Psychiatry. 1994 Jan;151(1):27-34. doi: 10.1176/ajp.151.1.27.
The authors sought to estimate the prevalence of simple schizophrenia, compare the clinical presentations and courses of simple and "typical" schizophrenia, and examine psychopathology in first-degree relatives of probands with simple schizophrenia, probands with typical schizophrenia, and community comparison subjects.
The authors followed up all individuals with a recorded diagnosis of schizophrenia (N = 285) and 75% of those with a diagnosis of severe affective illness (N = 99) from the Roscommon County Case Register, which includes all individuals seeking psychiatric care in a rural county in western Ireland. The authors interviewed all available first-degree relatives of these groups and of matched unscreened community comparison subjects.
Eleven cases of simple schizophrenia were diagnosed in the probands, for an estimated population prevalence and morbid risk in County Roscommon of 5.3 (SE = 1.6) and 6.2 (SE = 1.9) per 10,000, respectively. Individuals with typical schizophrenia (N = 126) had more marked delusions, hallucinations, and positive thought disorder; individuals with simple schizophrenia had more pronounced negative thought disorder and a more chronic course. Neither social/occupational functioning nor negative symptoms differed between the two groups. The risks for schizophrenia and all nonaffective psychoses were greater in the relatives of the probands with simple schizophrenia than in the relatives of the community comparison subjects.
In this sample, simple schizophrenia was relatively rare, was rather debilitating, and resembled typical schizophrenia in presentation and course except for the absence of positive psychotic symptoms. From a familial perspective, simple schizophrenia appears to be related to typical schizophrenia.
作者试图估算单纯型精神分裂症的患病率，比较单纯型与“典型”精神分裂症的临床表现及病程，并研究单纯型精神分裂症先证者、典型精神分裂症先证者及社区对照者的一级亲属的精神病理学。
作者对罗斯康芒郡病例登记册中所有记录有精神分裂症诊断的个体（N = 285）以及75%记录有重度情感障碍诊断的个体（N = 99）进行了随访，该登记册涵盖了爱尔兰西部一个乡村县所有寻求精神科护理的个体。作者对这些组以及匹配的未筛查社区对照者的所有可用一级亲属进行了访谈。
先证者中诊断出11例单纯型精神分裂症，罗斯康芒郡的估计人群患病率和患病风险分别为每10000人中有5.3（标准误 = 1.6）和6.2（标准误 = 1.9）。典型精神分裂症患者（N = 126）有更明显的妄想、幻觉和阳性思维障碍；单纯型精神分裂症患者有更明显的阴性思维障碍和更慢性的病程。两组之间的社会/职业功能及阴性症状并无差异。单纯型精神分裂症先证者的亲属患精神分裂症及所有非情感性精神病的风险高于社区对照者的亲属。
在该样本中，单纯型精神分裂症相对罕见，相当使人衰弱，除无阳性精神病性症状外，其临床表现和病程与典型精神分裂症相似。从家族角度来看，单纯型精神分裂症似乎与典型精神分裂症有关。
