透明质酸：一种多功能的、百万道尔顿的、隐形分子。

Hyaluronan: a multifunctional, megaDalton, stealth molecule.

作者信息

Lee J Y, Spicer A P

机构信息

Rowe Program in Genetics, Department of Biological Chemistry, University of California, Davis, School of Medicine, Tupper Hall, California 95616, Davis, USA.

出版信息

Curr Opin Cell Biol. 2000 Oct;12(5):581-6. doi: 10.1016/s0955-0674(00)00135-6.

DOI:10.1016/s0955-0674(00)00135-6

PMID:10978893

Abstract

Hyaluronan has been implicated in biological processes such as cell adhesion, migration and proliferation. Traditionally, it was thought to be associated with the extracellular matrix, but, hyaluronan may also have unimagined roles inside the cell. Investigation of hyaluronan synthesis and degradation, the identification of new receptors and binding proteins, and the elucidation of hyaluronan-dependent signaling pathways are providing novel insights into the true biological functions of this fascinating molecule.

摘要

透明质酸已被认为参与细胞黏附、迁移和增殖等生物学过程。传统上，人们认为它与细胞外基质有关，但透明质酸在细胞内可能也具有意想不到的作用。对透明质酸合成与降解的研究、新受体和结合蛋白的鉴定以及对透明质酸依赖性信号通路的阐明，正在为深入了解这种迷人分子的真正生物学功能提供新的见解。