蛋白水解在细胞表面及细胞表面之外的显著作用。

Remarkable roles of proteolysis on and beyond the cell surface.

作者信息

Blobel C P

机构信息

Cellular Biochemistry and Biophysics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA.

出版信息

Curr Opin Cell Biol. 2000 Oct;12(5):606-12. doi: 10.1016/s0955-0674(00)00139-3.

DOI:10.1016/s0955-0674(00)00139-3

PMID:10978897

Abstract

Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.

摘要

细胞表面和细胞外基质中的蛋白水解作用对于发育过程中和成体中的正常细胞功能至关重要，但它也可能产生不良后果，例如促进癌症、关节炎和阿尔茨海默病。最近的进展突出了锌依赖性金属蛋白酶（金属锌内肽酶）在正常骨骼发育、激活表皮生长因子受体配体、Notch依赖性信号传导以及启动和促进肿瘤发生中的作用。