Basbaum C B, Werb Z
Department of Anatomy, Box 0452, University of California, 3rd and Parnassus Avenue,s San Francisco, CA 94143-0452, USA.
Curr Opin Cell Biol. 1996 Oct;8(5):731-8. doi: 10.1016/s0955-0674(96)80116-5.
Cells respond to changes in their microenvironment by altering their cell surface and extracellular matrix proteins. Rapid and irreversible changes in these proteins are possible through their degradation or activation by proteolysis. By focalizing the proteolytic events at or near the cell surface, these processes can be effective even in the presence of high concentrations of inhibitors. Evidence is emerging that secreted and transmembrane matrix metalloproteinases, metalloproteinases of the adamalysin and astacin (tolloid) families, and serine proteinases are crucial in development, differentiation, cell motility and invasion, and cell-extracellular decisions.
细胞通过改变其细胞表面和细胞外基质蛋白来响应微环境的变化。这些蛋白质通过蛋白水解作用降解或激活，从而实现快速且不可逆的变化。通过将蛋白水解事件集中在细胞表面或其附近，即使存在高浓度抑制剂，这些过程也能有效进行。越来越多的证据表明，分泌型和跨膜基质金属蛋白酶、adamalysin和astacin（类 tolloid）家族的金属蛋白酶以及丝氨酸蛋白酶在发育、分化、细胞运动和侵袭以及细胞与细胞外的相互作用中起着关键作用。
