Niedzielska K, Kuran W, Barańska-Gieruszczak M, Romaniak A, Rzeski M, Poniatowska R, Karliński A, Zamysłowski S, Lecka J
Zakładu Neurofizjologii Klinicznej, Instytutu Psychiatrii i Neurologii w Warszawie.
Neurol Neurochir Pol. 2000 May-Jun;34(3):467-74.
The pathophysiological connection between periodic lateralized epileptiform discharges (PLED) and epileptic seizures is still not clear. In the study clinical data and EEG findings were analysed in 22 patients aged 43-90 years with a history of stroke in whom EEG disclosed PLED. Eleven patients were studied in the acute phase of stroke and 11 were studied years after stroke when the diagnosis was established of poststroke epilepsy. In 2 patients in acute stroke group single epileptic seizures occurred and 5 had partial status epilepticus. In the group with poststroke epilepsy 4 had single seizures and 4 had epileptic status with partial epilepsy seizures. Thus, in 15 out of 22 patients PLEDs were noted after epileptic seizures. In all cases PLED appearance was connected with consciousness disturbances, lasting 1 to 17 days. In 6 cases PLED pattern was interrupted by seizure activity over one hemisphere, in 3 of them partial epileptic seizures were associated with it. In acute phase of stroke neuroimaging demonstrated the presence of fresh ischaemic foci, but in cases of poststroke epilepsy no such fresh foci were observed. These results suggest that PLED frequently can be associated with epilepsy, and in some patients it can be a bioelectrical manifestation of partial status epileptic.
周期性一侧性癫痫样放电（PLED）与癫痫发作之间的病理生理联系仍不清楚。在该研究中，对22例年龄在43至90岁之间有中风病史且脑电图显示有PLED的患者的临床资料和脑电图结果进行了分析。11例患者在中风急性期接受研究，11例在中风数年之后被诊断为中风后癫痫时接受研究。在急性中风组中，2例发生单次癫痫发作，5例有部分性癫痫持续状态。在中风后癫痫组中，4例有单次发作，4例有部分性癫痫发作的癫痫持续状态。因此，22例患者中有15例在癫痫发作后出现PLED。在所有病例中，PLED的出现都与意识障碍有关，持续1至17天。在6例中，PLED模式被一侧半球的癫痫活动打断，其中3例伴有部分性癫痫发作。在中风急性期，神经影像学显示存在新鲜缺血灶，但在中风后癫痫病例中未观察到此类新鲜病灶。这些结果表明，PLED常与癫痫有关，在一些患者中它可能是部分性癫痫持续状态的生物电表现。
