Colasanti M, Suzuki H
IRCCS Lazzaro Spallanzani and Department of Biology, University ROMA TRE, Rome, Italy.
Trends Pharmacol Sci. 2000 Jul;21(7):249-52. doi: 10.1016/s0165-6147(00)01499-1.
In the body, nitric oxide (NO) is an important physiological regulator of functions such as vasodilatation and neurotransmission. Under pathological conditions, high concentrations of NO can be either beneficial(e.g. anti-bacterial, anti-parasitic and anti-viral) or detrimental; NO can therefore be considered a double-edged sword. When manipulating NO levels clinically, attention should be paid to minimize the negative effects and maximize the beneficial effects of NO. This article highlights recent evidence that supports the complexity of the regulatory mechanisms that lead to sophisticated endogenous NO production.
在体内，一氧化氮（NO）是血管舒张和神经传递等功能的重要生理调节因子。在病理条件下，高浓度的NO既可能有益（如抗菌、抗寄生虫和抗病毒），也可能有害；因此，NO可被视为一把双刃剑。在临床调控NO水平时，应注意尽量减少NO的负面影响，并最大化其有益作用。本文重点介绍了最近的证据，这些证据支持了导致复杂的内源性NO生成的调控机制的复杂性。
