非洲女性中单纯疱疹病毒2型与人类免疫缺陷病毒1型感染之间的相互作用：干预机会

Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention.

作者信息

Mbopi-Kéou F X, Grésenguet G, Mayaud P, Weiss H A, Gopal R, Matta M, Paul J L, Brown D W, Hayes R J, Mabey D C, Bélec L

机构信息

Central Public Health Laboratory, Enteric, Respiratory and Neurological Virus Laboratory, London NW9 5HT, UK.

出版信息

J Infect Dis. 2000 Oct;182(4):1090-6. doi: 10.1086/315836. Epub 2000 Sep 8.

DOI:10.1086/315836

PMID:10979904

Abstract

Sexually transmitted diseases (STDs) are cofactors for human immunodeficiency virus (HIV) transmission, but the specific role of herpes simplex virus type 2 (HSV-2) is unclear. This study aimed to examine the in vivo relationships between HSV-2 and HIV-1 in 300 women in Bangui, Central African Republic. Sera were tested for syphilis, HIV-1, HSV-2 antibody, and levels of vitamins A and E. Genital specimens were tested for other STDs. HSV-2 DNA and HIV-1 RNA were quantified in cervicovaginal lavage. The prevalences of HSV-2 antibody (91% vs. 78%, P=.02), HSV-2 shedding (43% vs. 22%, P=. 003), and levels of HSV-2 DNA (P=.01) were all significantly higher among HIV-1-seropositive than among HIV-1-seronegative women. There was a significant correlation between genital HIV-1 RNA and HSV-2 DNA levels (P=.02) among the 23 women who were shedding HSV-2 DNA. If confirmed, such associations highlight the urgent need for HSV-2 control measures in populations at high risk of both infections.

摘要

性传播疾病（STDs）是人类免疫缺陷病毒（HIV）传播的辅助因素，但2型单纯疱疹病毒（HSV-2）的具体作用尚不清楚。本研究旨在调查中非共和国班吉300名女性体内HSV-2与HIV-1之间的关系。检测血清中的梅毒、HIV-1、HSV-2抗体以及维生素A和E水平。检测生殖器标本中的其他性传播疾病。对宫颈阴道灌洗液中的HSV-2 DNA和HIV-1 RNA进行定量分析。HIV-1血清阳性女性中HSV-2抗体的患病率（91%对78%，P = 0.02）、HSV-2排毒率（43%对22%，P = 0.003）以及HSV-2 DNA水平（P = 0.01）均显著高于HIV-1血清阴性女性。在23名排出HSV-2 DNA的女性中，生殖器HIV-1 RNA与HSV-2 DNA水平之间存在显著相关性（P = 0.02）。如果得到证实，这种关联凸显了在两种感染的高危人群中采取HSV-2控制措施的迫切需求。