Choo S, Zhang Q, Seymour L, Akhtar S, Finn A
Division of Child Health, Sheffield Children's Hospital, Sheffield S10 2TH, UK.
J Infect Dis. 2000 Oct;182(4):1260-3. doi: 10.1086/315834. Epub 2000 Aug 31.
Salivary anticapsular antibody responses to a 7-valent pneumococcal conjugate vaccine (7VPnC) were measured in healthy infants. Infants received diphtheria-tetanus-pertussis/Haemophilus influenzae type b (DTP/Hib; group 1), DTP/Hib and 7VPnC (group 2), or DTP and 7VPnC/Hib (group 3) at ages 2, 3 and 4 months. All children received 23-valent pneumococcal polysaccharide vaccine at age 13 months. Salivary IgA and IgG responses to primary immunizations were generally poor. IgA mean concentrations at age 5 months were higher in the treatment groups than in control subjects for serotype 14 only (P<.001). At age 13-14 months, there were marked increases in IgA (mean fold difference, 3.7-4.9) and IgG (mean fold difference, 4. 1-11.7) levels for serotypes 4, 9V, 14, and 19F and serotypes 4, 18C, 19F, and 23F, respectively, in the treatment groups. This contrasts with low IgA (1.2 and 1.4) and IgG (1.3 and 2.2) mean fold differences for non-7VPnC serotypes 1 and 5. The results suggest that 7VPnC primes for mucosal memory responses in infants.
在健康婴儿中检测了针对7价肺炎球菌结合疫苗（7VPnC）的唾液抗荚膜抗体反应。婴儿在2、3和4月龄时分别接受白喉-破伤风-百日咳/ b型流感嗜血杆菌疫苗（DTP/Hib；第1组）、DTP/Hib和7VPnC（第2组）或DTP和7VPnC/Hib（第3组）。所有儿童在13月龄时均接种23价肺炎球菌多糖疫苗。对初次免疫的唾液IgA和IgG反应总体较差。仅对于血清型14，治疗组5月龄时的IgA平均浓度高于对照组（P<0.001）。在13 - 14月龄时，治疗组中血清型4、9V、14和19F以及血清型4、18C、19F和23F的IgA（平均倍数差异为3.7 - 4.9）和IgG（平均倍数差异为4.1 - 11.7）水平分别显著升高。这与非7VPnC血清型1和5的低IgA（1.2和1.4）和IgG（1.3和2.2）平均倍数差异形成对比。结果表明，7VPnC可激发婴儿的黏膜记忆反应。
