Genetic and epigenetic modification of MLH1.
作者信息
Perucho M
出版信息
Am J Pathol. 2000 Sep;157(3):1052-3. doi: 10.1016/s0002-9440(10)64618-4.
Abstract
摘要
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本文引用的文献
1
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.MLH1的基因和表观遗传修饰在微卫星不稳定型结直肠癌中占主要部分。
Am J Pathol. 2000 May;156(5):1773-9. doi: 10.1016/S0002-9440(10)65048-1.
2
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.具有或不具有CpG岛甲基化表型的结直肠肿瘤中的不同基因谱。
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):710-5. doi: 10.1073/pnas.97.2.710.
3
Genetic susceptibility to non-polyposis colorectal cancer.非息肉病性结直肠癌的遗传易感性。
J Med Genet. 1999 Nov;36(11):801-18.
4
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.表观遗传表型可区分微卫星稳定型和不稳定型结直肠癌。
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12661-6. doi: 10.1073/pnas.96.22.12661.
6
Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.致癌物代谢中的基因多态性及其与遗传性非息肉病性结直肠癌的关联。
Gastroenterology. 1998 Dec;115(6):1387-94. doi: 10.1016/s0016-5085(98)70017-4.
7
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.结直肠癌中hMLH1启动子高甲基化的发生率及功能后果
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5. doi: 10.1073/pnas.95.12.6870.
8
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.遗传性非息肉病性结直肠癌的发病率及该疾病分子筛查的可行性。
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