Shimada K, Watanabe Y, Mokuno H, Iwama Y, Daida H, Yamaguchi H
Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.
Am J Cardiol. 2000 Sep 15;86(6):682-4, A8. doi: 10.1016/s0002-9149(00)01054-7.
We investigated whether C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene predisposed to coronary atherosclerosis and acute myocardial infarction (AMI) in Japanese men. The frequencies of T allele and T/T homozygotes in patients with AMI were significantly higher than in controls and in patients with angina without prior AMI, suggesting that the CD14 promoter polymorphism is associated with AMI rather than with coronary atherosclerosis, and this polymorphism may be one of the genetic risk factors for AMI in Japanese men.
我们研究了日本男性中，CD14单核细胞受体基因启动子区域的C(-260)-->T多态性是否易导致冠状动脉粥样硬化和急性心肌梗死（AMI）。AMI患者中T等位基因和T/T纯合子的频率显著高于对照组以及无既往AMI的心绞痛患者，这表明CD14启动子多态性与AMI相关，而非与冠状动脉粥样硬化相关，并且这种多态性可能是日本男性AMI的遗传风险因素之一。
