Kelley R L, Kuroda M I
Baylor College of Medicinem, Department of Molecular and Cellular Biology, One Baylor Plaza, Mail Stop BCM235, Houston, Texas 77030, USA.
Curr Opin Genet Dev. 2000 Oct;10(5):555-61. doi: 10.1016/s0959-437x(00)00127-1.
Both flies and mammals remodel the architecture of the X chromosome to achieve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation.
果蝇和哺乳动物都会重塑X染色体的结构以实现剂量补偿。一类能覆盖整条染色体的新型非编码RNA在这一过程中起着核心作用。编码这些特殊RNA的基因本身就位于X染色体上，是针对X染色体进行剂量补偿的关键位点。
