遗传性胰腺炎的新见解

New insights into hereditary pancreatitis.

作者信息

Whitcomb D C

机构信息

University of Pittsburgh Medical Center, Division of Gastroenterology and Hepatology, 571 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

出版信息

Curr Gastroenterol Rep. 1999 Apr;1(2):154-60. doi: 10.1007/s11894-996-0015-7.

DOI:10.1007/s11894-996-0015-7

PMID:10980943

Abstract

The recent discovery that mutations in the trypsinogen gene are responsible for acute and chronic pancreatitis, and that patients with hereditary pancreatitis are at great risk for pancreatic cancer, has opened the door to understanding many aspects of pancreatic disease. This review focuses on the clinical presentation of hereditary pancreatitis, the mechanism of disease, and implications of this disease on understanding acute and chronic pancreatitis.

摘要

最近发现，胰蛋白酶原基因突变是急性和慢性胰腺炎的病因，且遗传性胰腺炎患者患胰腺癌的风险很高，这为了解胰腺疾病的诸多方面打开了大门。本综述重点关注遗传性胰腺炎的临床表现、发病机制以及该疾病对理解急性和慢性胰腺炎的意义。