Michalski B, Mazurek U, Olejek A, Kuśmierz D, Poreba R, Witek A, Wilczok T
Katedry i Oddziału Klinicznego, Połoznictwa i Ginekologii w Tychach.
Wiad Lek. 2000;53(5-6):240-6.
The aim of the study was a comparison of expression of angiogenesis genes: vascular endothelial growth factor (VEGF), KDR, suppressor gene p53, E6-HPV16 and HPV18, in tissue samples of normal, dystrophic, lymph nodes and malignant cancers of vulva and uterine cervix. The results demonstrate that molecular diagnostics of cancers using gene expression profiling indicates the definitive difference in expression profiles of aforementioned genes in tissues of the same malignancy.
血管内皮生长因子(VEGF)、激酶插入域受体(KDR)、抑癌基因p53、人乳头瘤病毒16型(HPV16)E6和人乳头瘤病毒18型(HPV18)在正常、营养不良、淋巴结以及外阴和子宫颈恶性癌组织样本中的表达情况。结果表明,利用基因表达谱进行癌症的分子诊断显示,在同一恶性肿瘤的组织中,上述基因的表达谱存在明显差异。