Nebert D W, Felton J S
Adv Exp Med Biol. 1975;58(00):127-49. doi: 10.1007/978-1-4615-9026-2_9.
Genetic differences in aromatic hydrocarbon "responsiveness" exist among various mouse strains. New formation of cytochrome P1-450 and the induction aryl hydrocarbon (benzo [a ])pyrene) hydroxylase (as well as numerous other monooxygenase activities) appear to be associated ultimately with genes that cosegregate at a small number of genetic loci. By comparing "responsive" and "nonresponsive" siblings, we can evaluate the susceptibility of each individual to various mutagenic chemicals in vitro or carcinogenic agents in vivo.
不同品系的小鼠在芳烃“反应性”方面存在基因差异。细胞色素P1 - 450的新形成以及芳烃（苯并[a]芘）羟化酶（以及许多其他单加氧酶活性）的诱导似乎最终与在少数基因位点共分离的基因相关。通过比较“反应性”和“无反应性”的同胞，我们可以评估每个个体在体外对各种诱变化学物质或体内对致癌剂的易感性。
