Matsumoto T, Yamanouchi K
Neuroendocrinology, Department of Basic Human Sciences, School of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, 359-1192, Saitama, Japan.
Neurosci Lett. 2000 Sep 22;291(3):143-6. doi: 10.1016/s0304-3940(00)01388-4.
To clarify the role of the ventromedial (VMH) or dorsomedial (DMH) hypothalamic nucleus in regulating male sexual behavior in female rats, radiofrequency or ibotenic acid lesions were made in ovariectomized rats, and three behavioral tests in total were carried out after implantation of Silastic tubes containing testosterone. As a result, females with radiofrequency or ibotenic acid lesions in the VMH showed higher levels of mounting behavior than those in females with no brain surgery or with sham-operation. The incidence of intromissive pattern in females with ibotenic acid lesions but not in females with radiofrequency lesions was higher than those in other female control groups. In the group of radiofrequency lesions in the DMH, both frequencies of mounting and intromissive pattern were lower than those in control and sham groups. No ejaculatory pattern was seen in any of the female groups. These results indicate that neuronal cell bodies in the VMH, but not in the DMH, exert an inhibitory influence on mounting activity in female rats.
为阐明腹内侧（VMH）或背内侧（DMH）下丘脑核在调节雌性大鼠雄性性行为中的作用，对去卵巢大鼠进行了射频或鹅膏蕈氨酸损伤，并在植入含睾酮的硅橡胶管后总共进行了三项行为测试。结果，VMH有射频或鹅膏蕈氨酸损伤的雌性大鼠的骑跨行为水平高于未进行脑部手术或假手术的雌性大鼠。鹅膏蕈氨酸损伤的雌性大鼠而非射频损伤的雌性大鼠的插入式行为发生率高于其他雌性对照组。在DMH射频损伤组中，骑跨和插入式行为的频率均低于对照组和假手术组。任何雌性组均未观察到射精行为。这些结果表明，VMH而非DMH中的神经元细胞体对雌性大鼠的骑跨活动具有抑制作用。
