Notch信号通路：Fringe确实是一种糖基转移酶。
Notch signaling: Fringe really is a glycosyltransferase.
作者信息
Blair S S
机构信息
Department of Zoology, University of Wisconsin, Madison 53706, USA.
出版信息
Curr Biol. 2000 Aug 24;10(16):R608-12. doi: 10.1016/s0960-9822(00)00633-3.
Abstract
Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch's developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch's glycosylation state.
摘要
边缘蛋白以对Notch的多种发育功能至关重要的方式改变Notch的配体选择性。最近的研究结果证实了一种猜测，即边缘蛋白是一种糖基转移酶，通过改变Notch的糖基化状态在高尔基体中发挥作用。
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