Tichý M, Stulík J, Osanec J, Skopek P
Purkyne Military Medical Academy, Czech Republic.
Neoplasma. 2000;47(2):118-21.
This report describes a new case of gamma-1-heavy chain disease found in a woman with malignant lymphoproliferative disease. The patient's serum and urine containing gamma-1-heavy chains were analyzed using different electrophoretic approaches, especially two-dimensional electrophoresis and immunoblotting analysis. In a serum sample, five sets of gamma-1-heavy chain spots differing in molecular weight with acidic pI values and one set of more basic gamma-1-heavy chain spots were found. The major group of spots exhibited molecular weight in the range from 29 to 39 kDa. Examination of urine sample proved the presence of the more basic set of gamma-1-heavy chain spots and two acidic groups, including 29 to 39 kDa set.
本报告描述了一名患有恶性淋巴增生性疾病的女性中发现的γ-1重链病新病例。使用不同的电泳方法，特别是二维电泳和免疫印迹分析，对患者含有γ-1重链的血清和尿液进行了分析。在一份血清样本中，发现了五组分子量不同且等电点呈酸性的γ-1重链斑点以及一组碱性更强的γ-1重链斑点。主要的斑点组分子量范围为29至39 kDa。对尿液样本的检测证实存在碱性更强的γ-1重链斑点组以及两个酸性组，包括29至39 kDa的组。
