Ryzhko I V, Tsuraeva R I, Samokhodkina E D, Shcherbaniuk A I, Mishan'kin B N, Koroleva N S, Anisimov B N
Research Plague Institute, Rostov-on-Don.
Antibiot Khimioter. 2000;45(7):10-3.
Mice immunization with reference vaccine at the early stage of plague infection provided animals survival and prolonged mean survival period up to 2-5 days. Ciprofloxacin, ofloxacin and pefloxacin prevents development of post vaccine immunity at white mice, immunized by reference vaccine strain EV. Nalidixic acid and norfloxacin effect on post vaccine immunity was lower. Use of immunogenic strain EV Nafr (resistant to nalidixic acid and fluoroquinolones) provided antiplague immunity formation at the background of fluoroquinolones prophylaxis. Ciprofloxacin, ofloxacin and pefloxacin used for plague prophylaxis at white mice infected with Yersinia pestis (about 1000 LD50) inhibited postinfective immunity development. Nalidixic acid and norfloxacin didn't demonstrate such effect. Urgent (fluoroquinolones) and specific (EV Nalr) combined prophylaxis was evaluated as more effective for a 5-day period and provided the development of antiplague immunity.
在鼠疫感染早期用参考疫苗免疫小鼠可使动物存活，并将平均存活期延长至2 - 5天。环丙沙星、氧氟沙星和培氟沙星可阻止经参考疫苗株EV免疫的小白鼠产生疫苗后免疫。萘啶酸和诺氟沙星对疫苗后免疫的影响较小。使用对萘啶酸和氟喹诺酮耐药的免疫原性菌株EV Nafr可在氟喹诺酮预防的背景下形成抗鼠疫免疫力。环丙沙星、氧氟沙星和培氟沙星用于预防感染鼠疫耶尔森菌（约1000 LD50）的小白鼠鼠疫时，会抑制感染后免疫的发展。萘啶酸和诺氟沙星未显示出这种效果。紧急（氟喹诺酮类）和特异性（EV Nalr）联合预防在5天内被评估为更有效，并能产生抗鼠疫免疫力。
