Use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation.
作者信息
Kraus J L, Bouygues M, Courcambeck J, Chermann J C
机构信息
Laboratoire de Chimie Biomoleculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France.
出版信息
Bioorg Med Chem Lett. 2000 Sep 4;10(17):2023-6. doi: 10.1016/s0960-894x(00)00393-0.
Abstract
The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is described. Anti-HIV recombinant protease assays and HIV infected cell culture assays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudopeptides.
摘要
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