Aligne C A, Auinger P, Byrd R S, Weitzman M
Strong Children's Research Center, Rochester General Hospital, and American Academy of Pediatrics Center for Child Health Research, Rochester, New York, USA.
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):873-7. doi: 10.1164/ajrccm.162.3.9908085.
The Child Health Supplement to the 1988 National Health Interview Survey was used to examine parent-reported current asthma among a nationally representative sample of 17,110 children zero to 17 yr of age. Numerous demographic variables were analyzed for independent associations with asthma using modified stepwise logistic regression, with models including specific combinations of risk factors. Black children had higher rates of asthma than did white children in unadjusted analyses, but after controlling for multiple factors, black race was not a significant correlate of asthma (adjusted odds ratio = 0.87, 95% CI = 0.63 to 1.21). Compared with nonurban white children, urban children, both black and white, were at significantly increased risk of asthma: urban and black (adjusted OR = 1.45, 95% CI = 1.14 to 1.86), urban and white (adjusted OR = 1.22, 95% CI = 1.01 to 1.48), whereas nonurban black children were not: nonurban and black (adjusted OR = 1.15, 95% CI = 0.83 to 1.61). Similarly, compared with nonurban, nonpoor children, urban and poor (adjusted OR = 1.44, 95% CI = 1.05 to 1.95), urban and nonpoor (adjusted OR = 1.22, 95% CI = 1.004 to 1.48), urban children, both poor and nonpoor, were at significantly increased risk of asthma, whereas nonurban poor children were not: nonurban and poor (adjusted OR = 1.03, 95% CI = 0.72 to 1.48). These results suggest that the higher prevalence of asthma among black children is not due to race or to low income per se, and that all children living in an urban setting are at increased risk for asthma.
1988年全国健康访谈调查的儿童健康补充调查被用于在一个全国代表性的17110名0至17岁儿童样本中,研究家长报告的当前哮喘情况。使用改良的逐步逻辑回归分析了众多人口统计学变量与哮喘的独立关联,模型包括危险因素的特定组合。在未经调整的分析中,黑人儿童的哮喘发病率高于白人儿童,但在控制了多个因素后,黑人种族与哮喘并无显著关联(调整后的优势比 = 0.87,95%置信区间 = 0.63至1.21)。与非城市白人儿童相比,城市儿童,包括黑人和白人,哮喘风险显著增加:城市黑人(调整后的优势比 = 1.45,95%置信区间 = 1.14至1.86),城市白人(调整后的优势比 = 1.22,95%置信区间 = 1.01至1.48),而非城市黑人儿童则不然:非城市黑人(调整后的优势比 = 1.15,95%置信区间 = 0.83至1.61)。同样,与非城市、非贫困儿童相比,城市贫困(调整后的优势比 = 1.44,95%置信区间 = 1.05至1.95)、城市非贫困(调整后的优势比 = 1.22,95%置信区间 = 1.004至1.48)儿童,无论贫困与否,哮喘风险均显著增加,而非城市贫困儿童则不然:非城市贫困(调整后的优势比 = 1.03,95%置信区间 = 0.72至1.48)。这些结果表明,黑人儿童中哮喘患病率较高并非由于种族或本身低收入所致,且所有居住在城市环境中的儿童哮喘风险均增加。