Keet Corinne A, Matsui Elizabeth C, McCormack Meredith C, Peng Roger D
Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md.
J Allergy Clin Immunol. 2017 Sep;140(3):822-827. doi: 10.1016/j.jaci.2017.01.036. Epub 2017 Mar 8.
Although poor-urban (inner-city) areas are thought to have high asthma prevalence and morbidity, we recently found that inner cities do not have higher prevalent pediatric asthma. Whether asthma morbidity is higher in inner-city areas across the United States is not known.
This study sought to examine relationships between residence in poor and urban areas, race/ethnicity, and asthma morbidity among children with asthma who are enrolled in Medicaid.
Children aged 5 to 19 enrolled in Medicaid in 2009 to 2010 were included. Asthma was defined by at least 1 outpatient or emergency department (ED) visit with a primary diagnosis code of asthma over the 2-year period. Urbanization status was defined at the county level and neighborhood poverty at the zip-code level. Among children with asthma, logistic models were created to examine the effects of urbanization, neighborhood poverty, and race/ethnicity on rates of asthma outpatient visits, ED visits, and hospitalizations.
This study included 16,860,716 children (1,534,820 with asthma). Among children enrolled in Medicaid, residence in inner-city areas did not confer increased risk of prevalent asthma in either crude or adjusted analyses, but it was associated with significantly more asthma-related ED visits and hospitalizations among those with asthma in crude analyses (risk ratio, 1.48; 95% CI, 1.24-1.36; and 1.97; 95% CI, 1.50-1.72, respectively) and when adjusted for race/ethnicity, age, and sex (adjusted risk ratio, 1.23; 95% CI, 1.08-1.15; and 1.62; 95% CI, 1.26-1.43). Residence in urban or poor areas and non-Hispanic black race/ethnicity were all independently associated with increased risk of asthma-related ED visits and hospitalizations.
Residence in poor and urban areas is an important risk factor for asthma morbidity, but not for prevalence, among low-income US children.
尽管人们认为城市贫困(市中心)地区哮喘患病率和发病率较高,但我们最近发现市中心地区儿童哮喘的患病率并不更高。美国市中心地区哮喘发病率是否更高尚不清楚。
本研究旨在探讨参加医疗补助计划的哮喘儿童中,居住在贫困和城市地区、种族/族裔与哮喘发病率之间的关系。
纳入2009年至2010年参加医疗补助计划的5至19岁儿童。哮喘的定义为在两年期间至少有1次门诊或急诊科就诊,主要诊断代码为哮喘。城市化状况在县一级定义,邻里贫困在邮政编码级别定义。在哮喘儿童中,建立逻辑模型以检验城市化、邻里贫困和种族/族裔对哮喘门诊就诊率、急诊科就诊率和住院率的影响。
本研究纳入了16860716名儿童(1534820名患有哮喘)。在参加医疗补助计划的儿童中,居住在市中心地区在粗分析或调整分析中均未增加哮喘患病率的风险,但在粗分析中,居住在市中心地区与哮喘患者中更多的哮喘相关急诊科就诊和住院显著相关(风险比分别为1.48;可信区间为95%CI,1.24 - 1.36;以及1.97;可信区间为95%CI,1.50 - 1.72),在调整种族/族裔、年龄和性别后(调整后风险比分别为1.23;可信区间为95%CI,1.08 - 1.15;以及1.62;可信区间为95%CI,1.26 - 1.43)。居住在城市或贫困地区以及非西班牙裔黑人种族/族裔均与哮喘相关急诊科就诊和住院风险增加独立相关。
在美国低收入儿童中,居住在贫困和城市地区是哮喘发病的重要危险因素,但不是患病率的危险因素。