Berti F, Müller E, De Gennaro Colonna V, Rossoni G
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Growth Horm IGF Res. 1998 Apr;8 Suppl B:149-52. doi: 10.1016/s1096-6374(98)80041-5.
Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH deficiency. The chronic administration of hexarelin to these GH-deficient rats had a pronounced protective effect against ischaemic and post-ischaemic ventricular dysfunction. Hexarelin prevented hyper-responsiveness of the coronary vascular bed to angiotensin II and also prevented the reduction in generation of 6-keto-prostaglandin F1alpha in perfused hearts from GH-deficient rats. The most plausible interpretation of these findings is that hexarelin acts via stimulation of specific cardiac and vascular receptors, triggering currently unknown cytoprotective mechanisms that are responsible for resistance to ischaemic insults and for the preservation of the integrity of the endothelial vasodilation function.
雄性大鼠用生长激素（GH）释放激素抗血清处理以诱导选择性GH缺乏。对这些GH缺乏的大鼠长期给予六肽生长激素释放肽对缺血性和缺血后心室功能障碍具有显著的保护作用。六肽生长激素释放肽可防止冠状血管床对血管紧张素II的高反应性，还可防止GH缺乏大鼠灌注心脏中6-酮-前列腺素F1α生成的减少。对这些发现最合理的解释是，六肽生长激素释放肽通过刺激特定的心脏和血管受体起作用，触发目前未知的细胞保护机制，这些机制负责抵抗缺血性损伤并维持内皮舒张功能的完整性。
