Baker K, McAlindon T
The Boston University Multipurpose Arthritis and Musculoskeletal Disease Center, Boston University School of Medicine, Massachusetts 02118, USA.
Curr Opin Rheumatol. 2000 Sep;12(5):456-63. doi: 10.1097/00002281-200009000-00020.
Adverse outcomes in knee osteoarthritis include pain, loss of function, and disability. These outcomes can have devastating effects on the quality of life of those suffering from the disease. Treatments have generally targeted pain, assuming that disability would improve as a direct result of improvements in pain. However, there is evidence to suggest that determinants of pain and disability differ. In general, treatments have been more successful at decreasing pain rather than disability. Many of the factors that lead to disability can be improved with exercise. Exercise, both aerobic and strength training, have been examined as treatments for knee osteoarthritis, with considerable variability in the results. The variability between studies may be due to differences in study design, exercise protocols, and participants in the studies. Although there is variability among studies, it is notable that a majority of the studies had a positive effect on pain and or disability. The mechanism of exercise remains unclear and merits future studies to better define a concise, clear exercise protocol that may have the potential for a public health intervention.
膝关节骨关节炎的不良后果包括疼痛、功能丧失和残疾。这些后果会对患该疾病者的生活质量产生毁灭性影响。治疗通常以疼痛为目标，假定残疾会随着疼痛的改善而直接改善。然而，有证据表明疼痛和残疾的决定因素不同。一般来说，治疗在减轻疼痛方面比减轻残疾更成功。许多导致残疾的因素可以通过运动得到改善。有氧运动和力量训练都已作为膝关节骨关节炎的治疗方法进行了研究，结果差异很大。研究之间的差异可能是由于研究设计、运动方案和研究参与者的不同。尽管研究之间存在差异，但值得注意的是，大多数研究对疼痛和/或残疾有积极影响。运动的机制仍不清楚，值得未来开展研究以更好地确定一个简洁、明确的运动方案，该方案可能具有公共卫生干预的潜力。
