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A comparison of the solubility of danazol in human and simulated gastrointestinal fluids.

作者信息

Pedersen B L, Müllertz A, Brøndsted H, Kristensen H G

机构信息

The Royal Danish School of Pharmacy, Department of Pharmaceutics, Copenhagen.

出版信息

Pharm Res. 2000 Jul;17(7):891-4. doi: 10.1023/a:1007576713216.

DOI:10.1023/a:1007576713216
PMID:10990211
Abstract
摘要

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本文引用的文献

1
Lysolecithin.溶血卵磷脂
J Pharm Pharmacol. 1961 Jun;13:321-54. doi: 10.1111/j.2042-7158.1961.tb11831.x.
2
Dissolution of hydrocortisone in human and simulated intestinal fluids.氢化可的松在人体和模拟肠液中的溶解情况。
Pharm Res. 2000 Feb;17(2):183-9. doi: 10.1023/a:1007517414200.
3
Gastric juice as a dissolution medium: surface tension and pH.胃液作为一种溶解介质:表面张力和pH值。
用于确定禁食状态下人体肠液生物等效平衡溶解度范围的小规模体外方法。
Eur J Pharm Biopharm. 2021 Nov;168:90-96. doi: 10.1016/j.ejpb.2021.08.002. Epub 2021 Aug 20.
4
Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid.药物的离子化对使用Capmul MCM和辛酸制备的自微乳化药物传递系统(SMEDDS)中药物增溶的影响。
Asian J Pharm Sci. 2017 Jan;12(1):73-82. doi: 10.1016/j.ajps.2016.10.001. Epub 2016 Nov 3.
5
Topography of Simulated Intestinal Equilibrium Solubility.模拟肠道平衡溶解度的地形学。
Mol Pharm. 2019 May 6;16(5):1890-1905. doi: 10.1021/acs.molpharmaceut.8b01238. Epub 2019 Apr 16.
6
Comparing human peritoneal fluid and phosphate-buffered saline for drug delivery: do we need bio-relevant media?比较人腹膜液和磷酸盐缓冲盐水在药物传递中的应用:我们需要生物相关的介质吗?
Drug Deliv Transl Res. 2018 Jun;8(3):708-718. doi: 10.1007/s13346-018-0513-9.
7
Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs.禁食和进食模拟肠液全浓度范围对口服药物平衡溶解度的统计研究。
Eur J Pharm Sci. 2018 Jan 1;111:247-256. doi: 10.1016/j.ejps.2017.10.007. Epub 2017 Oct 5.
8
Influence of Physiological Gastrointestinal Surfactant Ratio on the Equilibrium Solubility of BCS Class II Drugs Investigated Using a Four Component Mixture Design.采用四组分混合物设计研究生理胃肠道表面活性剂比例对 BCS Ⅱ类药物平衡溶解度的影响。
Mol Pharm. 2017 Dec 4;14(12):4132-4144. doi: 10.1021/acs.molpharmaceut.7b00354. Epub 2017 Aug 22.
9
Physiological parameters for oral delivery and in vitro testing.口服给药和体外测试的生理参数。
Mol Pharm. 2010 Oct 4;7(5):1388-405. doi: 10.1021/mp100149j. Epub 2010 Sep 7.
10
Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility.模拟人体升结肠内液体的生物相关介质及其在预测肠道内药物溶解度中的应用。
Pharm Res. 2010 Oct;27(10):2187-96. doi: 10.1007/s11095-010-0223-6. Epub 2010 Jul 30.
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):97-102. doi: 10.1007/BF03189322.
4
Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms.作为口服药物吸收预后工具的溶出度测试:速释剂型
Pharm Res. 1998 Jan;15(1):11-22. doi: 10.1023/a:1011984216775.
5
Characterization of fluids from the stomach and proximal jejunum in men and women.
Pharm Res. 1997 Apr;14(4):497-502. doi: 10.1023/a:1012107801889.
6
Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate.水不溶性药物体外测试的溶出介质:表面活性剂纯度和电解质对卡马西平在十二烷基硫酸钠水溶液中体外溶出的影响
J Pharm Sci. 1997 Mar;86(3):384-8. doi: 10.1021/js960105t.
7
Formation of lithogenic bile in man.人类成石性胆汁的形成。
Digestion. 1973;9(6):540-53. doi: 10.1159/000197483.
8
Upper gastrointestinal (GI) pH in young, healthy men and women.年轻健康男性和女性的上消化道pH值。
Pharm Res. 1990 Jul;7(7):756-61. doi: 10.1023/a:1015827908309.
9
Solubilization and wetting effects of bile salts on the dissolution of steroids.胆汁盐对类固醇溶解的增溶和湿润作用。
Pharm Res. 1991 Dec;8(12):1461-9. doi: 10.1023/a:1015877929381.