Noel A
Laboratoire de Biologie des tumeurs et du développement, l'Université de Liège au Sart Tilman.
Bull Mem Acad R Med Belg. 1999;154(6 Pt 2):347-53.
Breast carcinomas are composed of different compartments: tumor epithelial cells and host cells such as fibroblasts. Cancer progression and metastasis formation depend on complex interactions occurring between these two cell types. In response to the presence of tumour cells, fibroblasts secrete proteases able to degrade the extracellular matrix and to promote tumor invasion. These proteases are potential targets for anti-cancer agents.
肿瘤上皮细胞和宿主细胞，如成纤维细胞。癌症进展和转移的形成取决于这两种细胞类型之间发生的复杂相互作用。响应肿瘤细胞的存在，成纤维细胞分泌能够降解细胞外基质并促进肿瘤侵袭的蛋白酶。这些蛋白酶是抗癌药物的潜在靶点。
