Dhôte R, Dhôte-Burger P, Thevenot T, Devaux J Y, Beades E, Richard B, Christoforov B
Service de Médecine Interne, Hôpital Cochin, Paris, France.
J Clin Gastroenterol. 2000 Sep;31(2):152-5. doi: 10.1097/00004836-200009000-00013.
In Crohn's disease (CD), labeled leukocyte scintigraphy results are highly correlated with radioendoscopic findings and the degree of histologic inflammation. We evaluated the correlation between leukocyte activity measured by two complementary methods. polymorphonuclear leukocyte (PMN)-elastase concentration and leukocyte scintigraphy. In 20 patients with CD, labeled leukocytes, 99m technetium hexamethyl propylene amine oxime (99mTc-HMPAO) scintigraphy, and PMN-elastase concentration were evaluated on the same day. A good correlation was found between PMN-elastase concentrations and the scintigraphic scores (p = 0.005; rs = 0.60; 95% CI, 0.20-0.83). Scintigraphy results were significantly correlated with CD activity index (p = 0.023, rs = 0.50). In four patients, scintigraphic scores and clinical disease activity were not consistent due to the state of PMN leukocyte activation, measured by elastase concentration. In CD, PMN-elastase can provide information about the degree of activation of PMN leukocytes and may explain discrepancy between clinical and scintigraphic indexes.
在克罗恩病（CD）中，标记白细胞闪烁扫描结果与放射内镜检查结果及组织学炎症程度高度相关。我们评估了通过两种互补方法测量的白细胞活性之间的相关性，即多形核白细胞（PMN）-弹性蛋白酶浓度与白细胞闪烁扫描。对20例CD患者在同一天进行了标记白细胞、锝-99m六甲基丙烯胺肟（99mTc-HMPAO）闪烁扫描及PMN-弹性蛋白酶浓度评估。发现PMN-弹性蛋白酶浓度与闪烁扫描评分之间存在良好相关性（p = 0.005；rs = 0.60；95%可信区间，0.20 - 0.83）。闪烁扫描结果与CD活动指数显著相关（p = 0.023，rs = 0.50）。在4例患者中，由于通过弹性蛋白酶浓度测量的PMN白细胞活化状态，闪烁扫描评分与临床疾病活动不一致。在CD中，PMN-弹性蛋白酶可提供有关PMN白细胞活化程度的信息，并可能解释临床和闪烁扫描指标之间的差异。
