Tikhomirov V, Tikhomirova S, Sieber S, Schiffman M K
Department of Internal Medicine, Danbury Hospital, Connecticut 06810, USA.
J Clin Gastroenterol. 2000 Sep;31(2):172-4. doi: 10.1097/00004836-200009000-00019.
The unusual case of a young woman with pancreatitis recurring at onset of her menstrual periods is reported. The patient was diagnosed with pancreatic intraductal papillary mucinous tumor (IPMT). The temporal relation of clinical exacerbation of pancreatitis to the menstrual cycle is suggestive of a hormonal-mediated mechanism. The hypothesis of a possible role of progesterone receptors was dismissed with verification of the absence of progesterone and estrogen receptors in the neoplastic tissue. The possible role of activin A or inhibin A in our patient's clinical picture is theorized.
报告了一名年轻女性在月经周期开始时胰腺炎复发的罕见病例。该患者被诊断为胰腺导管内乳头状黏液性肿瘤（IPMT）。胰腺炎临床加重与月经周期的时间关系提示存在激素介导机制。通过证实肿瘤组织中不存在孕激素和雌激素受体，排除了孕激素受体可能起作用的假说。理论推测了激活素A或抑制素A在该患者临床表现中可能发挥的作用。
