Hartman M L
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA.
Growth Horm IGF Res. 1998 Feb;8 Suppl A:25-9. doi: 10.1016/s1096-6374(98)80005-1.
The Growth Hormone Research Society (GRS) convened a workshop in Port Stephens, Australia in April 1997 to establish consensus guidelines for the diagnosis and treatment of adults with GH deficiency (GHD). Scientists with expertise in the field, representatives from industry involved in the manufacture of GH and representatives from health authorities from a number of countries participated in the workshop. The workshop considered the following questions: (1) How should adult GHD be defined? (2) Who should be tested for adult GHD? (3) How should the diagnosis of adult GHD be established? (4) How should GH and insulin-like growth factor-I (IGF-I) assays be standardized? (5) Who should be treated for adult GHD? (6) What dose of GH should be used for treatment of adult GHD? (7) How should treatment of adult GHD be monitored? (8) What are the contraindications to treatment of adult GHD? (9) What safety issues need to be considered? (10) How long should treatment of adult GHD be continued? The consensus guidelines developed at this workshop and the rationale for some of these recommendations will be reviewed in this paper.
生长激素研究学会（GRS）于1997年4月在澳大利亚斯蒂芬斯港召开了一次研讨会，旨在为成人生长激素缺乏症（GHD）的诊断和治疗制定共识指南。该领域的专家科学家、生长激素生产行业代表以及多个国家卫生当局的代表参加了此次研讨会。研讨会讨论了以下问题：（1）应如何定义成人GHD？（2）哪些人应接受成人GHD检测？（3）应如何确立成人GHD的诊断？（4）生长激素和胰岛素样生长因子-I（IGF-I）检测应如何标准化？（5）哪些成人GHD患者应接受治疗？（6）治疗成人GHD应使用何种剂量的生长激素？（7）应如何监测成人GHD的治疗？（8）成人GHD治疗的禁忌证有哪些？（9）需要考虑哪些安全问题？（10）成人GHD治疗应持续多长时间？本文将对本次研讨会制定的共识指南以及其中一些建议的依据进行综述。
