帕金森病障碍中 Hoehn 和 Yahr 分期的进展：一项临床病理研究。
Progression of Hoehn and Yahr stages in Parkinsonian disorders: a clinicopathologic study.
作者信息
Müller J, Wenning G K, Jellinger K, McKee A, Poewe W, Litvan I
机构信息
Cognitive Neuropharmacology Unit, Henry M. Jackson Foundation, Bethesda, MD 20817-1844, USA.
出版信息
Neurology. 2000 Sep 26;55(6):888-91. doi: 10.1212/wnl.55.6.888.
The progression to different Hoehn and Yahr (HY) stages was evaluated in 81 pathologically confirmed patients with parkinsonism. Patients with PD (n = 18) showed significantly longer latencies to each HY stage than patients with atypical parkinsonian disorder (APD). While no patient with PD developed a HY-III stage within 1 year of onset of motor symptoms, 72% of those with APDs did. In fact, development of a HY-III within 1 year of motor onset accurately predicted an APD. However, the progression to each HY stage was unhelpful in distinguishing the APDs from each other. Once patients with PD and APD became wheelchair-bound, both had equally short survival times.
在81例经病理证实的帕金森病患者中评估了其向不同霍恩和雅尔（HY）分期的进展情况。帕金森病（PD）患者（n = 18）相较于非典型帕金森综合征（APD）患者，进入各HY分期的潜伏期显著更长。虽然没有PD患者在运动症状出现后1年内发展到HY-III期，但72%的APD患者出现了这种情况。事实上，在运动症状出现后1年内发展到HY-III期可准确预测为APD。然而，进展到各HY分期无助于区分不同类型的APD。一旦PD和APD患者需要依靠轮椅行动，两者的生存期都同样短暂。
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