Fanciulli Alessandra, Stankovic Iva, Avraham Omer, Jecmenica Lukic Milica, Ezra Adi, Leys Fabian, Goebel Georg, Krismer Florian, Petrovic Igor, Svetel Marina, Seppi Klaus, Kostic Vladimir, Giladi Nir, Poewe Werner, Wenning Gregor K, Gurevich Tanya
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.
Mov Disord Clin Pract. 2024 Apr 24;11(7):867-73. doi: 10.1002/mdc3.14048.
A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity.
To replicate and improve the 4-item MSA-P score.
We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up.
The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0-6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity.
The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.
基于直立性低血压、膀胱过度活动症、尿潴留和姿势性不稳中≥2项特征的4项评分，先前已显示能早期区分多系统萎缩帕金森型（MSA-P）和帕金森病（PD），敏感性为78%，特异性为86%。
复制并改进4项MSA-P评分。
我们回顾性研究了161例早期帕金森病患者[即病程≤2年或无姿势性不稳，年龄64（57；68）岁，44%为女性]，在随访≥24个月后确诊为临床确诊的MSA-P（n = 38）或PD（n = 123）。
4项MSA-P评分对最终MSA-P诊断的敏感性为92%，特异性为78%。通过将多巴胺能反应性和姿势畸形纳入6项评分（范围：0 - 6），疾病早期达到≥3分可识别出MSA-P患者，敏感性为89%，特异性为98%。
6项MSA-P评分是一种经济有效的工具，可精准识别早期MSA-P患者。
