Stoiber W, Sänger A M, Lembeck F
Institute of Zoology, University of Salzburg, Austria.
Arzneimittelforschung. 2000 Aug;50(8):683-7. doi: 10.1055/s-0031-1300273.
The Straub tail reaction in mice is an S-shaped dorsiflexion of the mouse tail, long known as a sensitive and specific bioassay for morphine (CAS 57-27-2). It is based on a contraction of the sacro-coccygeal dorsalis muscles. In the case of morphine the reaction is thought to be induced by a long-lasting stimulation of the muscle's motor innervation at the level of the lumbosacral spinal cord. A similar reaction caused by epibatidine differs pharmacologically, because in this case the reaction can be specifically inhibited by the ganglionic blocking agent mecamylamine. This points to a site of action of epibatidine (CAS 140111-52-0) at the neuromuscular junction of the sacro-coccygeal dorsalis muscles and requires the presence of muscle fibres which react to depolarization by sustained contraction. The present study provides evidence of the existence of such fibres using histochemical and immunohistochemical methods.
小鼠的施特劳布尾反应是小鼠尾巴呈S形背屈，长期以来一直被认为是检测吗啡（CAS 57-27-2）的一种灵敏且特异的生物测定法。它基于骶尾背侧肌的收缩。就吗啡而言，该反应被认为是由腰荐脊髓水平对肌肉运动神经支配的持久刺激所诱发。由埃皮巴蒂啶引起的类似反应在药理学上有所不同，因为在这种情况下，该反应可被神经节阻断剂美加明特异性抑制。这表明埃皮巴蒂啶（CAS 140111-52-0）在骶尾背侧肌的神经肌肉接头处有作用位点，并且需要存在通过持续收缩对去极化作出反应的肌纤维。本研究使用组织化学和免疫组织化学方法提供了此类纤维存在的证据。
