Wilensky A E, Schafe G E, LeDoux J E
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA.
J Neurosci. 2000 Sep 15;20(18):7059-66. doi: 10.1523/JNEUROSCI.20-18-07059.2000.
Although the lateral and basal nuclei of the amygdala are believed to be essential for the acquisition of Pavlovian fear conditioning, studies using post-training manipulations of the amygdala in the inhibitory avoidance learning paradigm have recently called this view into question. We used the GABA(A) agonist muscimol to functionally inactivate these nuclei immediately after single-trial Pavlovian fear conditioning or single-trial inhibitory avoidance learning. Immediate post-training infusions of muscimol had no effect on Pavlovian conditioning but produced a dose-dependent effect on inhibitory avoidance. However, pre-training infusions dose-dependently disrupted Pavlovian conditioning. These findings indicate that the amygdala plays an essential role in the acquisition of Pavlovian fear conditioning and contributes to the modulation of memory consolidation of inhibitory avoidance but not of Pavlovian fear conditioning.
虽然杏仁核的外侧核和基底核被认为对巴甫洛夫式恐惧条件反射的形成至关重要，但最近在抑制性回避学习范式中使用杏仁核训练后操作的研究对这一观点提出了质疑。我们使用GABA(A)激动剂蝇蕈醇在单次试验的巴甫洛夫式恐惧条件反射或单次试验的抑制性回避学习后立即功能性地使这些核失活。训练后立即注射蝇蕈醇对巴甫洛夫式条件反射没有影响，但对抑制性回避产生剂量依赖性效应。然而，训练前注射剂量依赖性地破坏了巴甫洛夫式条件反射。这些发现表明，杏仁核在巴甫洛夫式恐惧条件反射的形成中起重要作用，并有助于调节抑制性回避的记忆巩固，但对巴甫洛夫式恐惧条件反射的记忆巩固没有作用。
