Tammi A, Rönnemaa T, Viikari J, Jokinen E, Lapinleimu H, Ehnholm C, Simell O
Cardiorespiratory Research Unit, University of Turku, Kiinamyllynkatu 10, FIN-20520, Turku, Finland.
Atherosclerosis. 2000 Sep;152(1):135-41. doi: 10.1016/s0021-9150(99)00436-0.
As genetically determined apolipoprotein E (apo E) phenotypes influence serum cholesterol concentration, we analysed whether serum triglyceride values are also affected by the apo E phenotypes in infants. Non-fasting serum triglyceride values were measured in 7- and 13-month-old participants in the STRIP project, a randomised, prospective trial aimed at reducing children's exposure to known atherosclerosis risk factors (n=1062). The mean+/-S.D. non-fasting serum triglyceride concentrations in 7-month-old infants with apo E4/4 (n=36), E3/4 (n=209), E3/3 (n=412), and E2/3 (n=66) were 2. 05+/-1.24, 1.81+/-0.90, 1.63+/-0.90, and 1.71+/-0.83 mmol/l, respectively. Triglyceride concentrations were higher in infants with apo E4/4 or 3/4 than in those with apo E3/3 (P-value for difference 0.01 and 0.009, respectively). The apo E phenotype similarly influenced non-fasting serum triglyceride concentrations at the age of 13 months. The differences in serum triglyceride values in apo E4(+) infants (apo E3/4 and 4/4 infants combined) and apo E4(-) infants (apo E2/3 and 3/3 infants combined) occurred independently of the relative weight of the infant, milk type used at 7 months of age (breast milk or formula), and time elapsed from the previous meal. To conclude, apo E phenotypes regulate non-fasting serum triglyceride values in healthy infants. Apo E3/4 and apo E4/4 predispose infants to higher values than apo E3/3 phenotype, suggesting that the varepsilon4 allele may increase atherosclerosis risk also via it's effect on postprandial triglyceride metabolism.
由于基因决定的载脂蛋白E（apo E）表型会影响血清胆固醇浓度，我们分析了婴儿的血清甘油三酯值是否也受apo E表型的影响。在STRIP项目中，对7个月和13个月大的参与者测量了非空腹血清甘油三酯值，该项目是一项旨在减少儿童接触已知动脉粥样硬化风险因素的随机前瞻性试验（n = 1062）。apo E4/4（n = 36）、E3/4（n = 209）、E3/3（n = 412）和E2/3（n = 66）的7个月大婴儿的非空腹血清甘油三酯浓度均值±标准差分别为2.05±1.24、1.81±0.90、1.63±0.90和1.71±0.83 mmol/L。apo E4/4或3/4的婴儿甘油三酯浓度高于apo E3/3的婴儿（差异的P值分别为0.01和0.009）。apo E表型同样影响13个月大时的非空腹血清甘油三酯浓度。apo E4（+）婴儿（apo E3/4和4/4婴儿合并）和apo E4（-）婴儿（apo E2/3和3/3婴儿合并）的血清甘油三酯值差异与婴儿的相对体重、7个月大时使用的牛奶类型（母乳或配方奶）以及上次进食后的时间无关。总之，apo E表型调节健康婴儿的非空腹血清甘油三酯值。与apo E3/3表型相比，apo E3/4和apo E4/4使婴儿更容易出现较高的值，这表明ε4等位基因可能也通过其对餐后甘油三酯代谢的影响增加动脉粥样硬化风险。
