乙醇摄入对大鼠脑单胺氧化酶合成及其对不可逆抑制剂优降宁敏感性的刺激作用。

The stimulating effects of ethanol consumption on synthesis of rat brain monoamine oxidases and their sensitivity to the irreversible inhibitor, pargyline.

作者信息

Panova N G, Axenova L N, Medvedev A E

机构信息

Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogodinskaya street, 119832, Moscow, Russia.

出版信息

Neurosci Lett. 2000 Sep 29;292(1):66-8. doi: 10.1016/s0304-3940(00)01439-7.

DOI:10.1016/s0304-3940(00)01439-7

PMID:10996452

Abstract

Administration of a large dose of pargyline (60mg/kg) caused total irreversible inhibition of brain monoamine oxidases (MAOs) in both control and alcoholised rats. During the first 50h the recovery of brain MAO-A (but not MAO-B) activity occurred faster in the alcoholised rats. A low dose of pargyline (10mg/kg) produced significantly higher inhibition of MAO-A in the alcoholised rats, whereas the degree of MAO-B inhibition was the same in both groups. Brain MAOs of control and alcoholised rats exhibited similar sensitivity to pargyline in vitro. Since chronic ethanol feeding reduced the content of reversible endogenous MAO inhibitor, tribulin, higher pargyline-induced inhibition of MAO-A in alcoholised rats may stem from a tribulin deficit. The data obtained suggest that chronic ethanol consumption increases turnover of MAO-A molecules in the brain and reduces the content of endogenous MAO(A) inhibitors.

摘要

给对照组和酒精处理组大鼠注射大剂量的帕吉林（60mg/kg）会导致脑单胺氧化酶（MAO）完全不可逆抑制。在最初的50小时内，酒精处理组大鼠脑MAO-A（而非MAO-B）活性的恢复速度更快。低剂量的帕吉林（10mg/kg）对酒精处理组大鼠的MAO-A产生了显著更高的抑制作用，而两组中MAO-B的抑制程度相同。对照组和酒精处理组大鼠的脑MAO在体外对帕吉林表现出相似的敏感性。由于长期喂食乙醇会降低可逆性内源性MAO抑制剂三硫因的含量，帕吉林对酒精处理组大鼠MAO-A的更高抑制作用可能源于三硫因缺乏。所获得的数据表明，长期摄入乙醇会增加脑中MAO-A分子的周转率，并降低内源性MAO（A）抑制剂的含量。