Shimomura S, Kikuchi Y, Oka S, Ishitoya J
Department of Otorhinolaryngology, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, 162-8655, Tokyo, Japan.
Auris Nasus Larynx. 2000 Oct;27(4):335-8. doi: 10.1016/s0385-8146(00)00053-5.
Kaposi's sarcoma (KS) is frequently seen in the head and neck regions of HIV-infected patients. We report two cases of patients with AIDS who consulted the ENT clinic. One patient came to our clinic complaining of abnormal sensations in the pharynx, and dysphasia due to a gross KS in the oropharynx. The excision of the tumor improved the difficulty of swallowing. The other patient complained of masticatory problems and tongue pain due to a bulky KS on the dorsal side of the tongue. We treated the tongue lesion with intralesional chemotherapy. The administration of intralesional vinblastine resulted in a partial response. Unless systemic chemotherapy is effective enough to improve a functional disorder, it is thought that local therapy employing excision or intralesional chemotherapy is one of the common therapeutic option of the otolaryngologist, because this treatment avoids severe side effects caused by systemic chemotherapy or radiotherapy.
卡波西肉瘤（KS）常见于感染HIV患者的头颈部区域。我们报告两例到耳鼻喉科门诊就诊的艾滋病患者。一名患者因口咽部巨大KS前来我院，主诉咽部异常感觉及吞咽困难。肿瘤切除改善了吞咽困难。另一名患者因舌背巨大KS主诉咀嚼问题和舌痛。我们采用瘤内化疗治疗舌部病变。瘤内注射长春碱治疗取得部分缓解。除非全身化疗足以有效改善功能障碍，否则采用手术切除或瘤内化疗的局部治疗被认为是耳鼻喉科医生常用的治疗选择之一，因为这种治疗可避免全身化疗或放疗引起的严重副作用。
