Harada T, Namiki S, Kawabata I
Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Tsujido-cho, Kamoda, Kawagoe-shi, 350-8550, Saitama-ken, Japan.
Auris Nasus Larynx. 2000 Oct;27(4):359-62. doi: 10.1016/s0385-8146(99)00074-7.
This paper reports an unusual case in which acute lymphocytic leukemia presented acute profound sensorineural hearing loss as the initial manifestation of the disease. The patient is a 55-year-old woman who complained of left hearing loss of sudden onset. Pure tone audiometry revealed profound sensorineural hearing loss of the left ear at mid and low frequencies. The patient was tentatively diagnosed as idiopathic sudden deafness and admitted for the treatment, but her laboratory data indicated that she was at an advanced stage of leukemia. The patient's hearing loss did not improve subjectively until she deceased 1 year after the admission. The mechanism producing acute hearing loss in leukemic patients is reviewed and discussed, and the importance of differentiating possible underlying diseases before we diagnose idiopathic sudden deafness is stressed.
本文报道了一例罕见病例，急性淋巴细胞白血病以急性重度感音神经性听力损失作为该疾病的首发表现。患者为一名55岁女性，主诉突发左耳听力损失。纯音听力测试显示左耳中低频重度感音神经性听力损失。该患者初步诊断为特发性突发性聋并入院治疗，但实验室检查数据表明她处于白血病晚期。患者听力损失在入院1年后去世前主观上并未改善。本文回顾并讨论了白血病患者发生急性听力损失的机制，并强调了在诊断特发性突发性聋之前鉴别可能潜在疾病的重要性。
