Quigg M
NSF Center for Biological Timing, Department of Neurology, University of Virginia, Box 394, HSC, Charlottesville, VA 22908, USA.
Epilepsy Res. 2000 Nov;42(1):43-55. doi: 10.1016/s0920-1211(00)00157-1.
Circadian rhythms are endogenously-mediated 24 h cycles of behavioral or physiological activity. The interactions among the mammalian circadian clock, acute seizures, and chronic epilepsy are not well-characterized. Evidence suggests that seizures are susceptible to circadian modulation, and that this modulation varies with epilepsy syndrome and location of seizure foci. The circadian timing system and secondary circadian cycles of hormone secretion, sleep and wakefulness, and recurrent environmental factors are discussed as potential systems that effect spontaneous seizure recurrence. Experimental designs should take into account time-of-day effects on seizure threshold and occurrence. Further work is required to determine what mechanisms account for daily variation in seizure susceptibility.
昼夜节律是行为或生理活动的内源性介导的24小时周期。哺乳动物昼夜节律钟、急性癫痫发作和慢性癫痫之间的相互作用尚未得到充分表征。有证据表明，癫痫发作易受昼夜节律调节，且这种调节因癫痫综合征和癫痫病灶位置而异。昼夜节律计时系统以及激素分泌、睡眠和觉醒的次级昼夜周期，还有反复出现的环境因素被讨论为影响癫痫自发复发的潜在系统。实验设计应考虑一天中不同时间对癫痫发作阈值和发作的影响。需要进一步开展工作来确定导致癫痫易感性每日变化的机制。
