Vuong J S, York A, Garrett J, Connolly M J, Devergnas A
Yerkes National Primate Research Center, Atlanta, USA; Tufts University School of Medicine, USA.
Yerkes National Primate Research Center, Atlanta, USA.
Epilepsy Res. 2021 Dec;178:106805. doi: 10.1016/j.eplepsyres.2021.106805. Epub 2021 Nov 2.
Many people with epilepsy suffer from comorbid sleep disorders and sleep fragmentation. While the disruptive nature of seizures on sleep is well documented, it is unclear how diurnal seizures impact sleep quality and for how long these changes persist during the following nights. To better understand this relationship, the sleep architecture of two rhesus macaques were studied before and several nights after penicillin-induced diurnal seizures. These focal seizures stopped naturally, and none occurred at night. We scored sleep-stage during the nights immediately following the seizures, as well as several nights after seizure induction. We noted a significant increase in movement along with a decrease in sleep efficiency, both limited to the night of seizure induction. For both animals, we observed a significant decrease in the number of REM periods that manifested as a decrease in total REM sleep duration, and this phenomenon persisted up to 2 nights after the seizures. We also found a significant increase in the probability to transition from stage N2 to stage N1 on the night of the seizures. This study shows for the first time that the NHP model of penicillin-induced cortical seizures exhibits significant changes in sleep architecture, including an increase in nocturnal movement, change in sleep architecture and a prolonged decrease in REM activity. The prolonged decrease in REM periods compared to the temporary enhanced movement and reduction of sleep efficiency suggest that these seizures may affect two neural circuits, one controlling REM sleep entry and the other controlling nocturnal wakefulness.
许多癫痫患者患有合并睡眠障碍和睡眠片段化。虽然癫痫发作对睡眠的干扰性质已有充分记录，但尚不清楚白天发作如何影响睡眠质量以及这些变化在随后的夜晚会持续多长时间。为了更好地理解这种关系，研究了两只恒河猴在青霉素诱导的白天癫痫发作之前及之后几个晚上的睡眠结构。这些局灶性癫痫发作自然停止，且夜间未发作。我们在癫痫发作后的当晚以及发作诱导后的几个晚上对睡眠阶段进行了评分。我们注意到活动显著增加，同时睡眠效率下降，这两者都仅限于发作诱导的当晚。对于两只动物，我们观察到快速眼动（REM）期数量显著减少，表现为总REM睡眠时间减少，并且这种现象在癫痫发作后持续了2个晚上。我们还发现在癫痫发作当晚从N2期过渡到N1期的概率显著增加。这项研究首次表明，青霉素诱导的皮质癫痫发作的非人灵长类动物模型在睡眠结构上表现出显著变化，包括夜间活动增加、睡眠结构改变以及REM活动长期减少。与短暂的活动增强和睡眠效率降低相比，REM期的长期减少表明这些癫痫发作可能影响两个神经回路，一个控制REM睡眠的进入，另一个控制夜间觉醒。
